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针对采取小批量间歇性批次生产方式、工艺介质腐蚀性强、危险性大的小型特种精细化工生产工艺研究试验过程自动化、信息化程度不高,导致工艺研究试验中获取数据较少、过程机理研究不够透彻、人工操作多、安全风险高、研究试验消耗大及效率不高等问题,综述了期待通过智能控制、在线分析、模拟仿真和虚拟制造、工况监测及预测性维护以及信息管理和生产调度等关键技术的研究和应用,提高小型特种精细化工生产工艺过程的自动化和信息化程度,实现小型特种精细化工生产工艺过程的数字化、虚拟化和智能化,降低生产安全风险和试验消耗,提高小型特种精细化工生产工艺研究试验的成功率和效率,达到小型特种精细化工生产工艺过程的数字化设计和精准生产的目标。 相似文献
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TETSUYA OJIRO HIDEKI HONDA KAZUHIRO TSURUTA TSUYOSHI HANAMOTO 《Electrical Engineering in Japan》2018,203(2):39-46
At present, many industrial carrier devices utilize linear motor sliders. However, a heavier load requires a linear motor (which is an example of a direct drive device) to get higher power, compared with a rotary motor with a ball screw slider (which is an example of an indirect drive device). In order to obtain higher power at a lower cost, a linear slider with multiple motors can be utilized, for example, a gantry type linear motor slider. Moving the gantry type slider requires two linear motors that are set up in parallel to enable synchronization control. Some conventional synchronization control methods have been proposed for the parallel twin linear slider; however, a large‐scaled gantry type linear motor slider has two unique problems: mechanical distortion caused by the limitations of installation environment and coupling caused by joints with low stiffness. This paper proposes a control model to solve these problems, and an identification method of each parameter. Furthermore, the effectiveness of the control model is verified by comparison with simulation results and experimental results. 相似文献
47.
Parallel Multipopulation Differential Evolutionary Particle Swarm Optimization for Voltage and Reactive Power Control 下载免费PDF全文
This paper presents parallel multipopulation differential evolutionary particle swarm optimization (DEEPSO) for voltage and reactive power control (VQC). The problem can be formulated as a mixed integer nonlinear optimization problem and various evolutionary computation techniques have been applied to the problem including PSO, differential evolution (DE), and DEEPSO. Since VQC is one of the online controls, speed‐up of computation is required. Moreover, there is still room for improvement in solution quality. This paper applies parallel multipopulation DEEPSO in order to speed up the calculation and improve solution quality. The proposed method is applied to IEEE 30, 57, and 118 bus systems. The results indicate that the proposed method can realize fast computation and minimize more active power losses than the conventional evolutionary computation techniques. 相似文献
48.
Wenyuan Zhou Chasity P. Hankinson Prof. Dr. Alexander Deiters 《Chembiochem : a European journal of chemical biology》2020,21(13):1832-1836
We have developed a new tool for the optical control of cellular ATP concentrations with a photocaged adenylate kinase (Adk). The photocaged Adk is generated by substituting a catalytically essential lysine with a hydroxycoumarin-protected lysine through site-specific unnatural amino acid mutagenesis in both E. coli and mammalian cells. Caging of the critical lysine residue offers complete suppression of Adk's phosphotransferase activity and rapid restoration of its function both in vitro and in vivo upon optical stimulation. Light-activated Adk renders faster rescue of cell growth than chemically inducible expression of wild-type Adk in E. coli as well as rapid ATP depletion in mammalian cells. Thus, caging Adk provides a new tool for direct conditional perturbation of cellular ATP concentrations thereby enabling the investigation of ATP-coupled physiological events in temporally dynamic contexts. 相似文献
49.
Lokesh Kulhari Kanad Ray Ankit Paptan Nikhil Suri Pramod K Khanna 《International Journal of Applied Ceramic Technology》2020,17(3):1430-1439
Low temperature co-fired ceramic (LTCC) micro-hotplates show wide applications in gas sensors and micro-fluidic devices. It is easily structured in three-dimensional structures. This paper presents the low power consumption micro-hotplates which were developed with PTC (positive temperature coefficient) temperature sensor and inter-digitated electrodes. The paper presents two different structures for micro-hotplate with platinum as a heating element. The PTC temperature sensor using two different materials viz. PdAg and platinum paste are developed with micro-hotplates. The simulation has been achieved through COMSOL for LTCC and alumina micro-hotplates. The temperature variation with power consumption has been measured for the developed LTCC micro-hotplates. The change in resistance of PTC temperature sensors was measured with micro-hotplate temperature. The aim of this study was to place a temperature sensor with the gas sensor module to measure and control the temperature of micro-hotplate. A SnO2 sensing layer is coated on LTCC micro-hotplate using screen printing and characterized for the sensing of carbon monoxide gas (CO). This study will be beneficial for designing hotplates based on LTCC technology with low power consumption and better stability of temperature for gas-sensing applications. 相似文献
50.
Julio Flores-Gonzalez Juan Carlos Cancino-Díaz Leslie Chavez-Galan 《International journal of molecular sciences》2020,21(22)
Recent advances in the field of flow cytometry (FCM) have highlighted the importance of incorporating it as a basic analysis tool in laboratories. FCM not only allows the identification of cell subpopulations by detecting the expression of molecules in the cell membrane or cytoplasm, but it can also quantify and identify soluble molecules. The proper functioning of the FCM requires six fundamental systems, from those related to the transport of events to the systems dedicated to the analysis of information. In this review, we have identified the main considerations that every FCM user must know for an optimal antibody panel design, the quality systems that must govern the FCM protocols to guarantee reproducible results in research or clinical laboratories. Finally, we have introduced the current evidence that highlights the relevance of FCM in the investigation and clinical diagnosis of respiratory diseases, establishing important advances in the basic and clinical study of diseases as old as Tuberculosis along with the recent proposals for the monitoring and classification of patients infected with the new SARS-CoV2 virus. 相似文献